Can a PC gamer play online with soemone who has Xbox LIVE?

I was just wondering...|||i think you can for gears of war 1 i know theres achievements for PC GoW for the xbox 360.|||It all depends on the Game. I think it's possible with shadowrun.|||I think its possible but i wouldnt know for sure, google it.|||No its not possible, sorry.|||No.|||yep only for some games tho.|||did it nope